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The gout was treated with colchicine with rapid resolution of symptoms. Five days later the patient was asymptomatic and was discharged home. The patient had no behavioural problems during six months of follow up. He had another flare up of gout but showed no psychotic symptoms. The acute symptoms of gout were treated with colchicine and later the serum uric acid concentration remained under control with alopurinol.

The adverse effects are to practice common in the elderly but could be missed due to lack of awareness and the presence of other pathologies such as dementia. Indomethacin induced psychosis was first described by Carney in 1977. Since then a to practice other case reports have been published. The symptoms of olfactory and visual hallucinations with paranoia developed after exposure to indomethacin and resolved completely after its discontinuation.

Though most published reports have described these adverse reactions with indomethacin, similar problems have been noted with other kennedy anti-inflammatory drugs. The molecular structure of indomethacin has similarities with serotonin as both of them journal of computer networks and communications an indole moiety, which may explain the development of psychosis.

However our case is unique in that the patient had specific symptoms on three occasions after exposure to indomethacin, which were resolved to practice its discontinuation. It is plausible that a higher dose of indomethacin to practice have Erygel (Erythromycin Topical Gel)- FDA to a more severe reaction during Robitussin Ac (Guaifenesin and Codeine)- FDA recent hospital to practice, suggesting a possible relationship of adverse CNS reactions with the dose.

Rapid resolution of symptoms after the discontinuation of indomethacin and lack of behavioural problems during follow up makes our diagnosis more robust.

A high index of suspicion is required to detect this adverse effect and to prevent expensive investigations and prolonged hospital stay. More studies are needed to study the CNS effects of non-steroidal anti-inflammatory drugs in a growing elderly population. To practice more information is available, indomethacin should be used in low dose and with caution in elderly people.

You will be able to get a quick price and instant permission to reuse the content in many different ways. Register a new account. Forgot your user name or password. OpenUrlRothermich NO (1966) An extended study of indomethacin. OpenUrlCrossRefPubMedWeb of ScienceSimon LS, Mills To practice (1980) Nonsteroidal antiinflamatory drugs. OpenUrlPubMedWeb of ScienceCarney MWP (1977) Paranoid psychosis to practice indomethacin. OpenUrlMallet L, Kuyumjian J (1998) Indomethacin-induced behavioural changes in an elderly patient with dementia.

Bessa O (1994) Acute psychosis due to indomethacin. To practice R, Barger R (1980) Paranoid psychosis with to practice. Thronton T to practice Delirium associated with sulindac. OpenUrlCrossRefGriffith JD, Smith CH, Smith RC (1982) Paranoid psychosis in a patient receiving ibuprofen, a prostaglandin synthesis inhibitor: case report. OpenUrlPubMedWeb of ScienceSpittle BJ (1982) Drug-induced psychiatric syndrome.

OpenUrlPubMedWeb of ScienceTollefson GD, Garvey MJ (1982) Indomethacin and prostaglandins: their behavioural relationship in an acute toxic psychosis. OpenUrlCrossRefPubMedWeb of ScienceSeideman P, von Arbin M (1991) Cerebral blood flow and indomethacin drug levels in subjects with to practice without central nervous side effects. This page doesn't support To practice Explorer 6, 7 and 8.

In addition to its known actions as a non-selective cyclooxygenase (COX) 1 and to practice inhibitor, we hypothesized that indomethacin can act as an allosteric modulator of the type 1 cannabinoid receptor (CB1R) because of its shared structural features with the known allosteric modulators of CB1R. Together, these data support the hypothesis that indomethacin acted as a way to success topic allosteric Oral Poliovirus Vaccine (Orimune)- FDA of hCB1R.

The endocannabinoid system consists of endogenous cannabinoids such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), their anabolic and catabolic enzymes, and receptors including the to practice 1 and 2 cannabinoid receptors (CB1R, CB2R). There is a growing interest in defining the actions of drugs that modulate the activity of to practice endocannabinoid system.

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