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The National Committee for Clinical Laboratory Standards developed standardized reproducible and clinically relevant susceptibility testing roche diagnostics cobas for fungi. The therapeutic success rate among patients infected with susceptible isolates (MIC.

Mortality has been shown to increase in patients with candidemia who receive inappropriate fluconazole therapy. Garey et al performed a retrospective cohort study of patients with candidemia who were prescribed fluconazole at the onset of candidemia or later.

After controlling for covariates, each one-day delay in fluconazole therapy Mi-Mn associated with increased total hospital costs, and an adequate fluconazole dose was associated with decreased total hospital costs.

Inappropriate antimicrobial therapy has been shown to be an roche diagnostics cobas independent risk factor for mortality among hospitalized patients with serious infection, including bloodstream infections.

Conclusion The IDSA recommends fluconazole as an option for initial therapy of presumed candidemia. Clancy's data suggest that both fluconazole MIC and dose to MIC ratio correlate with the therapeutic response to fluconazole in patients with candidemia.

Patients unable to receive high-dose fluconazole (e. Rangel-Frausto MS, Wiblin T, Blumberg HM, et al. National Epidemiology of Mycoses Survey (NEMIS): variations in rates of blood stream infections due to Candida species in seven surgical intensive-care units, and six neonatal-intensive care units.

McNeil MM, Nash SL, Hajjeh RA, et al. Trends in mortality due to invasive mycotic disease in the United States, 1980-1997. Shifting patterns in the epidemiology of nosocomial Candida infections. Pittel D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients: roche diagnostics cobas length of stay, extra costs, and attributable mortality.

Wey SB, Mori M, Pfaller A, roche diagnostics cobas al. The attributable mortality and excess length of stay. Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study.

Guidelines for the treatment of candidiasis. Rentz AM, Halpern MT. Roche diagnostics cobas impact of candidemia on length of hospital stay, outcome, and overall cost of illness.

Zaoutis TE, Argon J, Chu J, et al. The epidemiology and roche diagnostics cobas outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis.

Rex JH, Bennett JE, Sugar AM, et al. A randomized trial comparing fluconazole with amphotericin B for treatment of candidemia in patients without neutropenia. Diflucan (fluconazole) package insert. Phillips P, Shafran S, Garber G, et al. Multicenter randomized trial of fluconazole versus amphotericin B for treatment of candidemia in non-neutropenic patients.

Eur J Clin Microbiol Infect Dis. Anaaisse EJ, Rex JH, Uzun O, et al. Predictors of adverse outcome in cancer patients with candidemia.

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